How do breast cancer cells bypass the blood-brain barrier (BBB) to colonize the brain? This study uncovers a ...

Among the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) ...

Abscisic acid (ABA) prevents cotyledon opening in the dark by modulating splicing through serine/arginine-rich (SR) proteins RS40 and RS41. Light reduces ABA levels, releasing this repression to allow ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002).MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

Chloride (Cl −) ions cause major damage to crops in saline soils.Understanding the key factors that influence Cl − uptake and translocation will aid the breeding of more salt-tolerant crops. Here, ...

Stroke is a major public health concern with a vast socioeconomic burden (Virani et al, 2021).Stroke is also the second leading cause of death and a leading cause of long‐term disability worldwide ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

In this study, we demonstrated that the druggable NCoR1/RARα axis is a promising target for selective inhibition of CMA in NSCLC. Furthermore, we developed CIM7, a first-in-class small molecule ...

It has been demonstrated that extrinsic factors play an essential role in the activation of EMH (Short et al, 2019).Overexpression of Tlx1, a transcription factor expressed in spleen stromal cells, ...

Histone posttranslational modifications (PTMs) such as ubiquitination, methylation and phosphorylation play a crucial role in gene transcription, DNA replication and repair (Chen and Tyler, 2022; ...

Telomerase deficiency in humans results in the development of telomere biology disorders (TBDs) that include idiopathic pulmonary fibrosis, dyskeratosis congenita and aplastic anemia (Armanios, ...