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Glycosylation of proteins in eukaryote cells is an important and complicated post-translation modification due to its pivotal role and association with crucial physiological functions within most of ...
Sometimes CDG occurs when defects affect and change multiple glycosylation pathways. For instance, a person can have defects that affect both N-linked and O-linked glycosylation pathways.
Glycosylation is a common post-translational modification (PTM) that plays a critical role in antibody effector functions. Comprehensive characterization of N- and O-linked glycosylation in protein ...
Comprehensive characterization of N- and O-linked glycosylation in protein therapeutics is essential for ensuring drug safety and efficacy. Accurate determination of glycosylation sites using ...
EBOV virus-like particles (VLPs) presenting the GP on rod-shaped particles generated by co-expression with VP40 protein were analyzed in order to identify the O-linked glycosylation sites on the GP.
FIGURE 1. Glycosylation profile on the recombinant RBD protein. Two N-glycosites and two O-glycosites were identified. Glycan cartoon structures are inferred from knowledge of common glycans as ...
Two types of human glycosylation are important for enveloped viruses like the SARS-CoV-2: the N-linked glycosylation and the mucin-type O-linked glycosylation, which are initiated by polypeptide ...
A team led by Katrine T. Schjoldager of the University of Copenhagen has now identified the largest number of O-linked glycosylated peptide hormones yet found (Nat. Commun. 2020, DOI: 10.1038 ...
O-linked glycosylation sites were also predicted using NetOGlyc (version 1.0) to examine sequence context. The glycosylation sites of the two viruses were compared based on the transmission course and ...
Crispin and his coworkers found that all 22 N-linked glycosylation sites are occupied most of the time (bioRxiv 2020, DOI: 10.1101/2020.03.26.010322).