The new Dietary Guidelines for Americans represent progress in some areas but raise concerns about transparency, internal consistency, practical implementation, and ignoring of key scientific evidence ...

After a physician pronounces his 15-year-old patient dead over the phone, he respects her parents’ silence, though it leaves him isolated in his grief and craving some form of closure.

Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components ...

Wheezing illnesses are a leading cause of hospitalization for preschool-age children and are frequently treated with antibiotics. Observational studies have shown more frequent isolation of three ...

Two phase 3, randomized trials of inhaled treprostinil for idiopathic pulmonary fibrosis (IPF) were conducted on the basis of preclinical and clinical evidence of an antifibrotic mechanism.

A 50-year-old woman was admitted to the hospital because of vaginal bleeding and anemia. She had a history of fibroids and 1 ...

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we ...

To the Editor: The recent reports of clinical benefit from the inhibition of the cytokine A proliferation-inducing ligand (APRIL) or dual inhibition of B-cell activating factor (BAFF) and APRIL in IgA ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 8).

Clinicians are rightly expected to disclose their gaps in knowledge or their inability to forecast an outcome. Yet emerging AI tools often cannot, or will not, do the same.