The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 2).

Ondansetron improves outcomes when administered in emergency departments to children with acute gastroenteritis–associated vomiting. It is commonly prescribed at discharge to reduce symptoms ...

The U.S. Supreme Court recently upheld Tennessee’s ban on gender-affirming hormonal treatment for transgender minors. This decision will have profound implications.

In 2006, a prospective observational study first showed that physical activity after a colon cancer diagnosis was linked to a decreased risk of recurrence and death.1 Since then, numerous observati ...

In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

Audio Interview from the New England Journal of Medicine — Interview with Patricia Mae Santos on the effects of U.S. anti-immigrant policies on immigrant health care workers and their patients.

A 59-year-old man presented with a 5-hour history of severe, pleuritic chest pain after vomiting. CT of the chest revealed air in the mediastinum extending up to the neck and perforation of the eso ...

The FDA’s announcement of a new “evidence-based approach to Covid-19 vaccination” represents a dramatic departure from both past practices and a commitment to transparency and gold-standard ...

Maridebart cafraglutide (known as MariTide) is a long-acting peptide–antibody conjugate that combines glucagon-like peptide-1 receptor agonism and glucose-dependent insulinotropic polypeptide ...