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Can targeting α-synuclein slow the course of Parkinson’s disease? Despite years of trying, success has eluded scientists thus far. At the AD/PD conference, held March 17-21 in Copenhagen, Denmark, ...

Clinicians have started using blood tests of p-tau217, a marker of amyloid plaques, to help diagnose AD in routine patient care, not just research studies. Alas, at AD/PD 2026, held March 17-21 in ...

Yes, you read that correctly, scientists are giving acetylcholine receptor drugs another whirl in Alzheimer’s. At the AD/PD conference, held March 17–21 in Copenhagen, Denmark, Manfred Windisch of NSC ...

In early symptomatic Alzheimer’s disease, amyloid immunotherapy confers but a slight cognitive benefit. Some scientists speculate that one reason could be the presence of other pathologies in the ...

The MAPT haplotypes H1 and H2 are defined by a large inversion polymorphism on chromosome 17. The HI haplotype has been consistently linked to risk for several neurodegenerative diseases, particularly ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

In a plenary at AD/PD, Bart De Strooper offered a vision of successive cellular struggles in Alzheimer’s pathophysiology, with key moments for therapeutic intervention.

Focused ultrasound with microbubbles is a noninvasive procedure that transiently opens the blood-brain barrier (BBB) using low-intensity sound waves. The openings reseal within 24 hours. Using MRI to ...

This transgenic (Tg) mouse overexpresses a mutant form of Lrrk2 (G2019S) using a bacterial artificial chromosome (BAC) (Li et al., 2010). Transgene expression is driven by the mouse Lrrk2 promoter ...