Purpose Children with Trisomy 21 are at increased risk of death compared to age-matched controls. We recently undertook a retrospective review of mortality in Trisomy 21 in our tertiary non-cardiac ...

Background Mental health problems are prevalent in children and young people (CYP). Children with neurodevelopmental disorders such as ASD have co-morbid mental health difficulties which add to the ...

Aims To explore the experiences and perceptions of senior medical and nursing staff regarding the advance care plan (ACP) in children and young persons (CYP) with life-limiting conditions and ...

Aims Maternal breastmilk (MBM) is the one of the most important interventions a preterm infant can receive. It reduces morbidity, improves neurodevelopmental outcome and reduces the incidence of ...

Objectives One in three children in England have Special Educational Needs (SEN) indicated at least once during school. We describe variation across neurodevelopmental conditions and in unaffected ...

Objectives Asthma is the most common chronic condition in children, affecting 2–3 in every primary school class.1 Asthma disproportionately affects children living in poverty due to air pollution, ...

Background The use of biologic agents allows the application of precision medicine in the treatment of paediatric severe asthma. Aim To describe the real-life effectiveness of biologic agents in ...

BACKGROUND In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of ...

Aims: To investigate long term effects of early adverse circumstances on cognitive function. Methods: Associations between early material home circumstances, parental divorce, maternal management and ...

On 20 February 2020, so-called Italian Patient 1 was admitted to the intensive care unit of his local hospital due to a deteriorating clinical condition from SARS-CoV-2/COVID-19 infection. In Italy, ...

Objective The aim of this research was to ascertain the effectiveness of current electronic prescribing (EP) systems to prevent a standardised set of paediatric prescribing errors likely to cause harm ...

One quarter of all adults in the UK are regular smokers, the vast majority having started smoking in their teens. Teenage smoking, especially in females, continues to increase both as regards the ...