The stars of the iconic drama will come together for a one-night-only charity event in New York City on Sept. 22.

The cast of Dawson's Creek will be back together onstage for the first time since the show wrapped in 2003 for a one-night only charity event to benefit F Cancer and Dawson’s Creek alum James Van Der Beek.

James Van Der Beek, Katie Holmes, Joshua Jackson, Michelle Williams and the rest of the "Dawson's Creek" cast will reunite for the first time in more than two decades.