Digital reconstruction of tiny, 400-million-year-old jawless fish shows how traits for evading predators gave rise to hunters ...

A research team from the University Hospital Bonn (UKB), the University of Bonn, and the Medical Center—University of ...

Researchers studying people with epilepsy have discovered that nerve cells in the medial temporal lobe coordinate their ...

A research team from the University Hospital Bonn (UKB), the University of Bonn, and the Medical Center - University of ...

The search for key regulatory factors associated with skeletal development is essential for exploring potential therapeutic targets for bone diseases. Nerve Growth Factor (NGF), the first neurotrophic ...

GLP-1 diabetes drugs like Ozempic found effective against migraines Messages Lost in Translation To find out how damaged nerves affect bones, the team studied the signals these nerves send.

But under diabetic conditions, this nerve-to-bone signaling was impaired, and instead of forming new bone, the periosteal cells started to shift towards fat cell differentiation (adipogenesis).

This reduction in nerve density also coincided with weakened bone structure, including a reduction in bone volume, cortical (outer bone) thickness as well as trabecular (inner spongy bone) density.