Notably, all immunoglobulins are glycosylated to varying degrees and glycosylation is an important posttranslational modification that affects many properties of proteins including folding, stability, ...

Glycosylation also occurs among proteins in the cytoplasm and nucleus through the actions of the Ogt glycosyltransferase, which produces a reversible O-linked β- N -acetylglucosamine (O -GlcNAc ...

Murine sperm initiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matrix of their homologous eggs. O-Glycans occupying two highly conserved vicinal ...

GALNT11 (Galnt11 in mice) encodes a member of the large glycosyltransferase family responsible for initiating mucin-type O-glycosylation of secreted and membrane-bound proteins (6, 7). The ortholog of ...

Protein glycosylation is an important posttranslational modification, of which the addition of N -acetylglucosamine (GlcNAc) to the Ser or Thr residue (O -GlcNAcylation) without further glycosylation ...

O-linked glycosylation involves the post-translational addition of the monosaccharide, GlcNAc, to a serine or threonine in target proteins. In contrast to N-linked glycosylation, there is no known ...

Scientists have developed an explainable AI tool called CANYA that deciphers the chemical language proteins use to determine whether they form clumps, which are linked to diseases like Alzheimer’s.