This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

Exercise rehabilitation has a long history in the management of chronic heart failure, with the first randomized trial of exercise training dating back to 1990 1 — and by the late 1990s, it had become ...

During the 6-year period, 7901 deaths occurred. The leading cause of maternal death was unintentional drug overdose (1152 deaths; 5.2 deaths per 100,000 live births). Violence (defined as homicide or ...

A 23-year-old man presented with a 2-day history of painful swallowing and hoarseness. The symptoms had started immediately after he had inhaled nitrous oxide through his mouth from a hand-held can ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 7).

A 60-year-old man presented with a 15-day history of generalized weakness and right upper abdominal pain. Imaging studies revealed diffuse disruption of the hepatic architecture by hyperechoic nodules ...

Mucormycosis is a rapidly progressive, invasive fungal infection that affects patients who are severely immunocompromised, as well as patients with diabetes and persons with immunocompetence who have ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 21).

Abstract To the Editor: We would like to address two potentially confusing issues concerning venous oxygen saturation (Svo 2) as presented in Table 1 of the review by Angus and van der Poll (Aug. 29 ...

In the management of breast cancer, treatment approaches are locoregional (i.e., surgery and radiotherapy) or systemic (i.e., chemotherapy, targeted therapy, endocrine therapy, and immunotherapy). The ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 6).