Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

In “Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor” by Singh et al, 2019, and “Transcript-specific induction of stop codon readthrough using a ...

Given the link to antiviral defenses, viruses have developed strategies to disrupt stress granule formation and even hijacked these factors to facilitate their replication (Eiermann et al, 2020; ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...

Colorectal cancer stands as the second leading cause of cancer-related mortality worldwide and ranks third in global cancer diagnoses. Despite the efficacy of surgical resection and adjuvant ...

Astrocytes are generated from radial glial cells (RGCs) in the ventricular zone during brain development (Kriegstein and Alvarez-Buylla, 2009; Lin et al, 2021).In the dorsal neocortex, RGCs express ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. PARP inhibitor (PARPi) resistance is a major ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The solute carrier 17 (SLC17) family contains ...

Hypoxia‐inducible factor (HIF), a heterodimeric transcription factor consisting of an oxygen‐sensitive HIF‐α subunit and a constitutively expressed HIF‐1β subunit, plays critical roles in the cellular ...

DDX5 is the most abundant RNA helicase and is aberrantly expressed in most malignant tumors, where it participates in transcriptional regulation, differentiation, metastasis, and regulation of various ...

Chloride (Cl −) ions cause major damage to crops in saline soils.Understanding the key factors that influence Cl − uptake and translocation will aid the breeding of more salt-tolerant crops. Here, ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...