Background GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear. Objective We aimed to investigate ...

Background Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study ...

Background Early-onset gastric cancer (EOGC) is a lethal malignancy. It differs from late-onset gastric cancer (LOGC) in clinical and molecular characteristics. The current strategies for EOGC ...

Institute of Liver Studies, King's College Hospital, London. The insertion of percutaneous endoscopic gastrostomy has been well documented. The possible benefits for patient nutrition and nursing ...

Chronic liver disease is a cluster of disorders associated with complex haemodynamic alterations, which is characterised by structural and functional disruptions of the intrahepatic and extrahepatic ...

Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.

Background Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive coeliac serology. We present the first, multicentre, ...

The incidence of multidrug resistant (MDR) organisms in spontaneous bacterial peritonitis (SBP) is increasing, shifting from gram-negative to gram-positive organisms. There are recent safety concerns ...

Introduction Maximising efficiency in endoscopy in the face of increasing service pressure, demand and complexity of endoscopy is imperative, particularly given the unparalleled impact of the COVID ...

Objective To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United ...

Conflict of interest statement.Professor Irvine shares ownership of the copyright, together with McMaster University, of the Inflammatory Bowel Disease Questionnaire (IBDQ). Modern medicine has had a ...