Europe PMC

Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.

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Europe PMC

Indian Academy of Pediatrics Revised (2021) Guidelines on Prevention and Treatment of Vitamin D Deficiency and Rickets.

The emerging literature on prevalence of vitamin D deficiency in India, prevention and treatment strategies of rickets, and extra-skeletal benefits of vitamin D suggest the need for revising the ...
Europe PMC

Structures and ion transport mechanisms of plant high-affinity potassium transporters.

Europe PMC is an archive of life sciences journal literature.
Europe PMC

FastGWA-GLMM: a generalized linear mixed model association tool for biobank-scale data

Compared to linear mixed model-based genome-wide association (GWA) methods, generalized linear mixed model (GLMM)-based methods have better statistical properties when applied to binary traits but are ...
Europe PMC

Identification of an episignature for CHD3-related Snijders Blok-Campeau syndrome reveals heterogeneity in the CHARGE syndrome episignature: towards a better characterization ...

A preprint is a complete scientific manuscript that an author uploads on a public server for free viewing. Initially it is posted without peer review, but may acquire feedback or reviews as a preprint ...
Europe PMC

Synthesis, structure, hirshfeld surface analysis, non-covalent interaction, and in silico studies of 4-hydroxy-1-[(4-nitrophenyl)sulphonyl]pyrrolidine-2-carboxyllic acid

The new compound 4-hydroxy-1-[(4-nitrophenyl)sulphonyl]pyrrolidine-2-carboxyllic acid was obtained by the reaction of 4-hydroxyproline with 4-nitrobenzenesulphonyl chloride. The compound was ...
Europe PMC

Effect of αvβ3 Blockade Against Acute Lung Injury Induced by Influenza A Virus and Its Mechanism

Integrin αvβ3 is a heterodimer formed by αv and β3 subunits that is expressed in pulmonary endothelial cells, alveolar epithelial cells, interstitial cells and macrophages. Integrin αvβ3 not only has ...
Europe PMC

Fluoride occurrences, health problems, detection, and remediation methods for drinking water: A comprehensive review.

Fluoride contamination has become a considerable threat to our society worldwide. Fluoride in drinking water is primarily due to rich fluoride soil, volcanic activity, forage, grasses and grains, and ...
Europe PMC

Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance.

Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance.
Europe PMC

Lichens as a useful mapping tool?--an approach to assess atmospheric N loads in Germany by total N content and stable isotope signature.

To assess whether nitrogen (N) content and δ(15)N ratios in nitrophytic lichen species (Xanthoria parietina (L.) Th. Fr. (1860) and Physcia spp. (Schreb.) Michaux (1803)) reflect the quantity and ...
Europe PMC

Psychosocial Factors in Knee Osteoarthritis: Scoping Review of Evidence and Future Opportunities.

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Europe PMC

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator ...

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD + salvage pathway. Since NAD + plays a pivotal role in many biological processes including metabolism and ...