Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT.

Alternative lengthening of telomeres (ALT) supports telomere maintenance in 10–15% of cancers, thus representing a compelling target for therapy. By performing anti-cancer compound library screen on ...

In the quest to unlock the secrets of aging and longevity, telomeres have emerged as key players. These protective caps at the ends of our chromosomes play a critical role in cellular aging. With each ...

Telomeres are the "caps" that protect the ends of DNA strands from being destroyed by a cell. They are made up of areas of repeated DNA sequences combined with specific proteins at the ends of ...

Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...

Telomeres — the “caps” on the end of chromosomes that protect the DNA from damage — have been associated with greater longevity. In theory, longer telomeres should allow a cell to divide more times ...

Scientists investigate human telomere length to elucidate aging and diseases such as cancer and neurodegenerative disorders. In normal mammalian cells, a small telomeric DNA segment is lost after each ...

MADISON — Researchers at the University of Wisconsin–Madison have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new ...

Alternative lengthening of telomeres cells, or ALT cells, have long presented a challenge for researchers and oncologists alike. Unlike other cancer cells, which use the enzyme telomerase to lengthen ...

University of North Carolina (UNC) researchers Taghreed Al-Turki, PhD, and Jack Griffith, PhD, have made the discovery that the telomeres on the ends of chromosomes contain genetic information that ...

There’s a new argument against “junk DNA.” In this microscope image, the ends of chromosomes are protected by specific DNA sequences called telomeres, visualized here in red. Credit: National ...