Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H ...

In eukaryotes, DNA is tightly wound into a complex structure called chromatin. The basic packaging unit of DNA is the nucleosome core, consisting of 147 bp of DNA tightly wrapped around a histone ...

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

This is a preview. Log in through your library . Abstract The effect of hyperthermia (40-48°C) on the nucleosome structure of mammalian chromatin was determined using the enzyme micrococcal nuclease.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 11, [Part 2: Biological Sciences] (Nov., 1981), pp. 6803-6807 (5 pages) Switches of the types of histones ...

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Research reveals that five DNA letters can switch chromatin between fluid and solid-like states, influencing gene ...

It takes a lot of packaging to squeeze DNA into the nucleus of a cell. The DNA in our chromosomes is packaged into nucleosomes, which consist of about 150 DNA base pairs wrapped around eight-protein ...

Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information. Newly published research by Cynthia Wolberger, Ph.D., ...