Ganji M et al., and Fudenberg G et al., postulated that the SMC family of ATPases, such as condensin and cohesion, extrude DNA into large loops. Energy from ATP hydrolysis helps the SMC proteins to ...

It is one of the great mysteries in biology: How does a cell neatly distribute its replicated DNA between two daughter cells? For more than a century, we have known that DNA in the cell is comparable ...

A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works.

How does a meter-long strand of DNA fit inside a cell without forming a tangled mess? This accomplishment comes courtesy of structural maintenance of chromosomes (SMC) proteins, which orchestrate the ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

A human cell carries in its nucleus two meters of spiraling DNA, split up among the 46 slender, double-helical molecules that are its chromosomes. Most of the time, that DNA looks like a tangled ball ...

Researchers recorded the folding dynamics of the human genome over time, creating a novel 4-D map of genome organization. Simulation of DNA organized into two globules by loop extrusion. The figure-8 ...

DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes. DNA, or deoxyribonucleic acid, is the genetic ...

It is one of the mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter cells? Scientists are split into two camps: the first argues that condensing works like ...

Remarkably, living cells are able to package a jumble of DNA over two meters in length into tidy, tiny chromosomes while preparing for cell division. However, scientists have been puzzled for decades ...