To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption. Most lipids are made in a cell organelle called the ...

Interest in lipid nanoparticles (LNPs) as delivery vehicles for precision therapies in genetic diseases and cancers remains at an all-time high. Now, scientists from the University of Pennsylvania, ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

The latest short science news items from C&EN. A complicated sequence of events follows once an RNA drug is injected into the body. After the lipid-packaged RNA arrives at a cell, it pushes through ...

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The bottom of the ocean is not hospitable: there is no light, the temperature is freezing cold, and the pressure of all the water above will literally crush you. The animals that live at this depth ...