Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 25 (Dec. 10, 1996), pp. 14405-14410 (6 pages) Duocarmycin A (Duo) normally alkylates adenine N3 at the 3 ′ ...
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high mutation rates and failure to engage DNA-damage-induced apoptosis. DNA ...
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