B lymphocytes (or B cells) descend from bone marrow (BM) hematopoietic stem cells (HSC) and mediate humoral immunity by secreting antibodies. Early studies based on a selected set of surface and ...
The E3 ubiquitin ligase Casitas B-lineage lymphoma (CBL) promotes positive selection and antigen responses in mouse T lymphocytes by ubiquitinating ZAP70. Conversely, mouse CBL and CBL-B mutually ...
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