Albert Breer and Kyle Brandt argue that San Francisco 49ers coach Kyle Shanahan deserves consideration for the 2025 NFL Coach of the Year award.

The San Francisco 49ers brought in Asante Samuel Jr. for a workout on Monday, evaluating the veteran cornerback as he works his way back into the NFL after undergoing spinal fusion surgery during the offseason. Samuel had visited several teams in recent weeks, and on Tuesday,...

San Francisco 49ers tight end George Kittle (85) catches a touchdown pass in front of Arizona Cardinals linebacker Akeem Davis-Gaither (27) during the first half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin

NBC Sports Bay Area asked the 49ers Faithful how many games San Francisco will win to close out the 2025 NFL regular season.

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

San Francisco 49ers head coach Kyle Shanahan provided an unfortunate injury return timeline update for Brandon Aiyuk.

While the 49ers waived Martinez to make room for defensive end Clelin Ferrell, they're not planning on Martinez being gone long according to head coach Kyle Shanahan. Shanahan on Monday in a conference call said Martinez was an option to return to the practice squad. NFL Media's Ian Rapoport later reported Martinez would be rejoining the 49ers.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.